Thought this was interesting, plus it has a connection to NCSU!


"Gold Nanoparticles Resurrect Failed HIV Drug
Eric Bland, Discovery News



May 21, 2008 -- The metaphorical gold standard of medical treatment might one day turn out to be a literal gold treatment.

By hacking off the ends of a failed HIV drug and sticking the resulting molecules onto gold nanoparticles, scientists have stopped HIV from infecting lab-cultured white blood cells. It is the first time gold nanoparticles have shown potential in therapies for HIV.

The same technique could eventually be put to use in treatments for a variety of diseases, say researchers not associated with the new study.

In the early 1990's scientists tested a drug called TAK779, which successfully prevented HIV from binding to human white blood cells but caused such severe side effects that it was ruled out as a useful therapy.

The problem-causing component of the drug molecule appeared to be an ammonium salt on one end. Lopping off that salt prevents the side effects, but it also renders the drug useless against HIV. The resulting molecule simply won't bind to the virus tightly enough.

By attaching the drug (minus the ammonium salt) to gold nanoparticles, researchers hoped to improve the drug's binding power to HIV.

Since gold is chemically inert, reacting to virtually nothing, it is ideal not only for jewelry but also for use inside the body. The idea is to use the much larger gold nanoparticles to shepherd around and concentrate the smaller, weakly binding drug molecules.

"It's the same idea as Velcro," said T. Eric Ballard, a scientist at North Carolina State University and a co-author on the new study, which was recently published online in the Journal of the American Chemical Society. "One interaction is weak, but if you have a lot of weak interactions together they make one strong interaction."

It worked. The researchers tested several ratios of drug molecules to nanoparticles and found that when each nanoparticle was equipped, on average, with 12 drug molecules, the drug appeared to be as effective against HIV as the original version with the side effect-inducing ammonium salt."

http://dsc.discovery.com/news/2008/05/21/gold-nanoparticles.html for the rest of the article.

5/22/2008 12:57:04 PM

awesome

5/22/2008 12:58:09 PM

that's cool as shit

5/22/2008 1:02:03 PM

Southpark did it

5/22/2008 1:19:15 PM

^.

5/22/2008 1:47:55 PM

^^ genius.

5/22/2008 1:50:38 PM

Quote :

"T. Eric Ballard, a scientist at North Carolina State University"

hahahahaha a SCIENTIST


that's great. He's a grad student upstairs. I wish I had that pic of him from when he was in high school. HUGE FRO lol.



my research is way awesomer.


[Edited on May 22, 2008 at 3:57 PM. Reason : .]

5/22/2008 3:56:21 PM

How do I get a scientist degree?

5/22/2008 4:06:56 PM

Embed fight song plz

Go State!

5/22/2008 4:11:07 PM

Quote :

"T. Eric Ballard, a scientist at North Carolina State University"

haha holy shit this dude was my TA for organic 2 in like 04, and he was awesome

explained concepts way better than the professor

5/22/2008 7:10:50 PM

omg Eric lol

he was my RA for 2 years

cool as shit

5/22/2008 7:22:21 PM

how can we not cure this shit....seems like we aint cured shit since polio...now we just prolong death

[Edited on May 22, 2008 at 7:36 PM. Reason : and small pox]

5/22/2008 7:36:38 PM

So money could be the cure for AIDS just like in South Park?

5/22/2008 7:45:07 PM

^haha yes

5/22/2008 7:48:21 PM

i texted eric and apparently we're all going to see indiana jones tonight

if it wasnt for meganey2004 I wouldnt be seeing Indiana Jones tonight!

5/22/2008 8:34:59 PM

I can't wait until rappers start talking about bling bling their AIDS is

"I gots gold in my veins, nigga"

5/23/2008 1:04:24 AM

Hey, that's really cool. I hope they're able to make something of this.

I imagine using gold wouldn't cost that much considering the cost of the HIV medicine. This is exactly what the pharm companies want: A working treatment for HIV.

Now if only they could find a way to cure HIV...

5/23/2008 2:09:19 AM